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Advances in cardiovascular molecular imaging for tracking stem cell therapy

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Topic:

Stem cells in cardiovascular biology and medicine

DOI: http://dx.doi.org/10.1160/TH09-08-0530
Issue: 2010: 104/1 (July) pp. 1-190
Pages: 13-22

Advances in cardiovascular molecular imaging for tracking stem cell therapy

K. J. Ransohoff (1, 2), J. C. Wu (1, 2)

(1) Department of Medicine (Division of Cardiology), Stanford University School of Medicine, Stanford, California, USA; (2) Department of Radiology, Molecular Imaging Program at Stanford (MIPS), Stanford University School of Medicine, Stanford, California, USA

Keywords

Magnetic Resonance, stem cells, imaging, fluorescence, cell transplantation, radionuclide, bioluminescence

Summary

The high mortality rate associated with cardiovascular disease is partially due to the lack of proliferative cells in the heart. Without adequate repair following myocardial infarction, progressive dilation can lead to heart failure. Stem cell therapies present one promising option for treating cardiovascular disease, though the specific mechanisms by which they benefit the heart remain unclear. Before stem cell therapies can be used safely in human populations, their biology must be investigated using innovative technologies such as multi-modality molecular imaging. The present review will discuss the basic principles, labelling techniques, clinical applications, and drawbacks associated with four major modalities: radionuclide imaging, magnetic resonance imaging, bioluminescence imaging, and fluorescence imaging.

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