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Tissue factor and thrombosis: The clot starts here

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Topic:

Theme Issue: Highlights from EMVBM 2009

DOI: http://dx.doi.org/10.1160/TH09-11-0771
Issue: 2010: 104/3 (Sep) pp. 421–653
Pages: 432-439

Tissue factor and thrombosis: The clot starts here

A. P. Owens III (1), N. Mackman (1)

(1) Division of Hematology/Oncology, Department of Medicine, University of North Carolina at Chapel Hill, Chapel Hill, North Carolina, USA

Keywords

thrombosis, Venous thrombosis, Animal models, Arterial thrombosis, tissue factor / factor VII

Summary

Thrombosis, or complications from thrombosis, currently occupies the top three positions in the cardiovascular causes of morbidity and mortality in the developed world. There are a limited number of safe and effective drugs to prevent and treat thrombosis. Animal models of thrombosis are necessary to better understand the complex components and interactions involved in the formation of a clot. Tissue factor (TF) is required for the initiation of blood coagulation and likely plays a key role in both arterial and venous thrombosis. Understanding the role of TF in thrombosis may permit the development of new antithrombotic drugs. This review will focus on the role of TF in in vivo models of thrombosis.

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