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Unfavourable cardiovascular disease risk profiles in a cohort of Dutch and British haemophilia patients

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
DOI: http://dx.doi.org/10.1160/TH12-05-0332
Issue: 2013: 109/1 (Jan) pp. 1–173
Pages: 16-23

Unfavourable cardiovascular disease risk profiles in a cohort of Dutch and British haemophilia patients

D. E. Fransen van de Putte (1), K. Fischer (1, 2), M. Makris (3), R. C. Tait (4), P. Chowdary (5), P. W. Collins (6), K. Meijer (7), G. Roosendaal (1), R. E. G. Schutgens (1), E. P. Mauser-Bunschoten (1)

(1) Van Creveldkliniek, Department of Haematology, University Medical Center Utrecht, Utrecht, The Netherlands; (2) Julius Center for Health Sciences and Primary Care, University Medical Center Utrecht, Utrecht, The Netherlands; (3) Sheffield Haemophilia and Thrombosis Centre, Royal Hallamshire Hospital, Sheffield, UK; (4) West of Scotland Haemophilia and Thrombosis Centre, Royal Infirmary, Glasgow, UK; (5) Katharine Dormandy Haemophilia Centre and Thrombosis Unit, Royal Free Hospital, London, UK; (6) Arthur Bloom Haemophilia Centre, School of Medicine, Cardiff University and University Hospital of Wales, Cardiff, UK; (7) Division of Haemostasis and Thrombosis, Department of Haematology, University Medical Center Groningen, Groningen, The Netherlands

Keywords

Cardiovascular Disease, hypertension, Haemophilia, QRISK, risk profile

Summary

Cardiovascular disease (CVD) mortality is reported to be decreased in haemophilia patients, but reports on the prevalence of CVD risk factors are conflicting. A cross-sectional assessment of CVD risk profiles was performed in a large cohort of haemophilia patients. Baseline data on CVD risk factors of 709 Dutch and UK haemophilia patients aged ≥30 years were analysed and compared with the general age-matched male population. CVD risk profiles were assessed using the QRISK®2–2011 and SCORE algorithms. Although QRISK® 2 was only validated in the UK, comparison with SCORE indicated similar properties of QRISK®2 in both Dutch and UK patients (correlation 0.86). Mean age was 49.8 years. Hypertension was more common in haemophilia patients than in the general population (49% vs. 40%), while the prevalences of obesity and hypercholesterolaemia were lower (15 vs. 20% and 44 vs. 68%, respectively), and those of diabetes and smoking were similar. The predicted 10-year QRISK®2 risk was significantly higher in haemophilia patients than in the general population (8.9 vs. 6.7%), indicating more unfavourable cardiovascular disease risk profiles. This increased risk became apparent after the age of 40 years. Our results indicate an increased prevalence of hypertension and overall more unfavourable CVD risk profiles in haemophilia patients compared with the general age-matched male population.

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