Contact Person

Dr. Elinor Switzer

Managing Editor

Phone: +49 (0)711 - 2 29 87 63
Fax: +49 (0)711 - 2 29 87 65
send an Email


The physiological and pathophysiological roles of platelet CLEC-2

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Issue: 2013: 109/6 (June) pp. 977–1185
Pages: 991-998

The physiological and pathophysiological roles of platelet CLEC-2

L. Navarro-Núñez (1), S. A. Langan (1), G. B. Nash (1), S. P. Watson (1)

(1) Centre for Cardiovascular Sciences, Institute for Biomedical Research, College of Medical and Dental Sciences, University of Birmingham, Birmingham, UK


Platelets, lymphangiogenesis, CLEC-2, podoplanin


CLEC-2 is a C-type lectin receptor which is highly expressed on platelets but also found at low levels on different immune cells. CLEC-2 elicits powerful platelet activation upon engagement by its endogenous ligand, the mucin-type glycoprotein podoplanin. Podoplanin is expressed in a variety of tissues, including lymphatic endothelial cells, kidney podocytes, type I lung epithelial cells, lymph node stromal cells and the choroid plexus epithelium. Animal models have shown that the correct separation of the lymphatic and blood vasculatures during embryonic development is dependent on CLEC-2-mediated platelet activation. Additionally, podoplanin-deficient mice show abnormalities in heart, lungs, and lymphoid tissues, whereas absence of CLEC-2 affects brain development. This review summarises the current understanding of the molecular pathways regulating CLEC-2 and podoplanin function and suggests other physiological and pathological processes where this molecular interaction might exert crucial roles.

You may also be interested in...

Sasidhar Guthikonda1, Kirankumar Mangalpally1, Muthiah Vaduganathan1, Rajnikant Patel2, Timothy DeLao1, Angela L. Bergeron3, Jing-Fei Dong3, Eli I. Lev1, Neal S. Kleiman1

Thromb Haemost 2008 100 1: 83-89

Ok-Nam Bae*1, Young-Dae Kim*1, Kyung-Min Lim1,2, Ji-Yoon Noh1, Seung-Min Chung1, Keunyoung Kim1, Suyoung Hong1, Sue Shin3, Jong-Hyun Yoon3, Jin-Ho Chung1

Thromb Haemost 2008 100 1: 52-59

Jing-fei Dong1,2*, Miguel A. Cruz1, Khatira Aboulfatova1, Cecilia Martin1, Hiuwan Choi1, Angela L. Bergeron1, Sheryl R. Martini3, Michael H. Kroll1,2, Thomas A. Kent3

Thromb Haemost 2008 99 3: 586-593