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Gaps in translation from trials to practice: Non-vitamin K antagonist oral anticoagulants (NOACs) for stroke prevention in atrial fibrillation

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Topic:

Theme Issue
New oral anticoagulants for stroke prevention in atrial fibrillation

DOI: http://dx.doi.org/10.1160/TH13-12-1032
Issue: 2014: 111/5(May) pp. 781-1006
Pages: 783-788
Ahead of Print: 2014-02-27

Gaps in translation from trials to practice: Non-vitamin K antagonist oral anticoagulants (NOACs) for stroke prevention in atrial fibrillation

Theme Issue Article for Theme Issue "Novel oral anticoagulants"

E. M. Hylek (1), D. Ko (1), C. L. Cove (1)

(1) Boston University School of Medicine, Department of Medicine, Boston, Massachusetts, USA

Summary

Worldwide there is a tremendous need for affordable anticoagulants that do not require monitoring. The advent of the non-warfarin oral anticoagulant drugs represents a major advance for stroke prevention in atrial fibrillation (AF). The objectives of this review are to 1) identify gaps in our current knowledge regarding use of these single target anticoagulant drugs; 2) outline the potential implications of these gaps for clinical practice, and thereby, 3) highlight areas of research to further optimise their use for stroke prevention in AF.