Contact Person

Dr. Elinor Switzer

Managing Editor

Phone: +49 (0)711 - 2 29 87 63
Fax: +49 (0)711 - 2 29 87 65
send an Email


Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245

Thrombotic microangiopathies: New developments and translation into medicine

Issue: 2009: 101/2 (Feb) pp. 217-412
Pages: 359-366

Uncarboxylated matrix Gla protein (ucMGP) is associated with coronary artery calcification in haemodialysis patients

Ellen C. M. Cranenburg1,*; Vincent M. Brandenburg2,*; Cees Vermeer 1; Melanie Stenger 2; Georg Mühlenbruch 3; Andreas H. Mahnken 3; Ulrich Gladziwa 4; Markus Ketteler 2; Leon J. Schurgers1
1 VitaK and Cardiovascular Research Institute Maastricht (CARIM), Maastricht University, Maastricht, The Netherlands; 2 Department of Nephrology and Clinical Immunology, RWTH University Hospital Aachen, Germany; 3 Department of Diagnostic Radiology, RWTH University Hospital Aachen, Germany; 4 Department of Internal Medicine, University of Witten/Herdecke, Germany


Gla-domain proteins, vitamin K, matrix Gla protein, Dialysis, calcification


Matrix γ-carboxyglutamate (Gla) protein (MGP) is a potent local inhibitor of cardiovascular calcification and accumulates at areas of calcification in its uncarboxylated form (ucMGP). We previously found significantly lower circulating ucMGP levels in patients with a high vascular calcification burden. Here we report on the potential of circulating ucMGP to serve as a biomarker for vascular calcification in haemodialysis (HD) patients. Circulating ucMGP levels were measured with an ELISA-based assay in 40 HD patients who underwent multi-slice computed tomography (MSCT) scanning to quantify the extent of coronary artery calcification (CAC). The mean ucMGP level in HD patients (193 ± 65 nM) was significantly lower as compared to apparently healthy subjects of the same age (441 ± 97 nM; p < 0.001) and patients with rheumatoid arthritis (RA) without CAC (560 ± 140 nM; p < 0.001). Additionally, ucMGP levels correlated inversely with CAC scores (r = –0.41; p = 0.009), and this correlation persisted after adjustment for age, dialysis vintage and high-sensitivity C-reactive protein (hs-CRP). Since circulating ucMGP levels are significantly and inversely correlated with the extent of CAC in HD patients, ucMGP may become a tool for identifying HD patients with a high probability of cardiovascular calcification.

You may also be interested in...


E. C. M. Cranenburg (1), R. Koos (2), L. J. Schurgers (1), E. J. Magdeleyns (1), T. H. M. Schoonbrood (3), R. B. Landewé (3), V. M. Brandenburg (2, 4), O. Bekers (5), C. Vermeer (1)

Thromb Haemost 2010 104 4: 811-822

Ellen C. M. Cranenburg, Leon J. Schurgers, Cees Vermeer

Thromb Haemost 2007 98 1: 120-125


Leon J. Schurgers, Ellen C. M. Cranenburg, Cees Vermeer

Thromb Haemost 2008 100 4: 593-603