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Chemokines as mediators of angiogenesis

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Topic:

Chemokines in vascular biology

DOI: http://dx.doi.org/10.1160/TH07-01-0040
Issue: 2007: 97/5 (May) pp. 685-872
Pages: 755-762

Chemokines as mediators of angiogenesis

Borna Mehrad1, Michael P. Keane2, Robert M. Strieter1

1Division of Pulmonary and Critical Care Medicine, University of Virginia, Charlottesville, Virginia, USA; 2Division of Pulmonary and Critical Care Medicine, David Geffen School of Medicine at University of California, Los Angeles, California, USA

Keywords

cancer, angiogenesis, Chemokine, chemokine receptor

Summary

Chemokines were originally described as cytokines that mediate leukocyte recruitment to sites of inflammation. Members of a subgroup of chemokines, the CXC family, also play a critical role in both physiologic and pathologic angiogenesis, including in the context of chronic inflammation, fibrosis, and malignancy.A unique feature of this family of cytokines is that, on the basis of their structure and receptor binding, individual ligands display either angiogenic or angiostatic biological activity in the regulation of angiogenesis. In this review, we summarize the key literature in this growing field.

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