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Vasa vasorum and atherosclerosis – Quid novi?

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
DOI: http://dx.doi.org/10.1160/TH06-12-0742
Issue: 2007: 97/6 (June) pp. 873-1060
Pages: 873-879

Vasa vasorum and atherosclerosis – Quid novi?

Alexander C. Langheinrich1, Marian Kampschulte1, Thomas Buch1, Rainer M. Bohle²
1University of Giessen, Department of Radiology, Giessen, Germany; 2University of Homburg/Saar, Department of Pathology, Homburg/Saar, Germany

Keywords

Atherosclerosis, inflammation, Vasa vasorum, intraplaque hemorrhage

Summary

The role of vasa vasorum (VV) in atherosclerosis is hotly debated, and new experimental techniques have recently opened an opportunity to take a fresh look at this important topic.Although the proliferation ofVV due to atherogenic stimuli is controversial, experimental and clinical evidence strongly suggest the potential ofVV in vascular proliferative disorders.In the past, paradigms of atherosclerosis and restenosis have excluded the adventitia andVV in the artery wall due, in part, to a lack of i) appropriate animal models featuring adventitial VV neovascularization, ii) imaging technologies to quantitate adventitial VV and plaque neovascularization and iii) its consequences, concerning information on detectable plaque substrate in vulnerable lesions. VV proliferation is associated with increasing plaque burden and is linked to cellular processes which are critical during the development of atherosclerotic plaques such as inflammation, plaque perfusion and concomitant intraplaque hemorrhage – but the regulation and induction ofVV based on pathological settings are poorly understood. This review discusses the current scientific status and its controversies and identifies open research questions.

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