Advertisement
Advertisement
http://2015.eurothrombosis.eu

Contact Person

Dr. Elinor Switzer

Managing Editor

Phone: +49 (0)711 - 2 29 87 63
Fax: +49 (0)711 - 2 29 87 65
send an Email


Archive

Factor V Leiden mutation and pregnancy-related venous thromboembolism. What is the exact risk? Results from a meta-analysis

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
DOI: http://dx.doi.org/10.1160/TH06-02-0086
Issue: 2006: 96/1 (July) pp. 1-103
Pages: 14-18

Factor V Leiden mutation and pregnancy-related venous thromboembolism. What is the exact risk? Results from a meta-analysis

Christine Biron-Andreani 1, Jean-Francois Schved 1, Jean-Pierre Daures 2
1 Hopital Saint-Eloi, Laboratoire d' Hematologie, Montpellier, France; 2 IURC, Laboratoire de Recherche en Biostatistiques et Epidemiologie, Montpellier, France

Keywords

factor V Leiden mutation, Venous thrombosis, pregnancy, metaanalysis

Summary

The magnitude of the association of factor V Leiden mutation with pregnancy-related venous thrombosis remains unclear. Our objective was to undertake a systematic review and a metaanalysis of the literature to estimate precisely the association of factorV Leiden mutation with the risk of first, or recurrent, pregnancy- related venous thromboembolism. Studies published before October 2005 were identified by Medline® . Using both fixed and random effect models, odds ratios (OR) with accompanying 95% confidential intervals (CI) were calculated for the factor V Leiden mutation and the clinical end-point (Yusuf-Peto adaptation of the Mantel-Haenszel, DerSimonian and Laird method). We identified 13 studies including 7 cohorts and 6 casecontrol studies relating to factor V Leiden and pregnancy-related venous thrombosis.The results from the cohorts showed a pooled OR of 4.46 (95% CI,1.82–10.94;7,879 pooled women), with no evidence of statistical heterogeneity (p=0.36), for the risk of a first venous thromboembolism during pregnancy or the postpartum period associated with the factor V Leiden mutation. Case-control studies revealed a higher risk ( OR 8.6, 95% CI, 5.85–12.63; 1,524 pooled women) with significant heterogeneity (p<0.005). Because of insufficient data, an analysis for the risk of recurrence could not be performed. Our findings emphasize the fact that limited data are available on this topic. This meta-analysis provides clinicians with an estimate of the average risk of a first thrombosis occurring during pregnancy in women carrying the factor V Leiden to assist the management of such women.

You may also be interested in...

1.
André Kher1, Rupert Bauersachs2, Jorn Dalsgaard Nielsen3

Thromb Haemost 2007 97 4: 505-513

http://dx.doi.org/10.1160/TH06-10-0606

2.
R. Vormittag, I. Pabinger

Hämostaseologie 2006 26 1: 59-62

3.
A population-based case-control study

A. Bergrem (1, 2, 3), A. E. A. Dahm (1, 2), A. F. Jacobsen (4), L. Sandvik (5), P. M. Sandset (1, 2, 3)

Thromb Haemost 2012 108 6: 1165-1171

http://dx.doi.org/10.1160/TH12-05-0350