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Tissue plasminogen activator in central nervous system physiology and pathology

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Topic:

Xth International Workshop on Molecular and Cellular Biology of Plasminogen Activation

DOI: http://dx.doi.org/10.1160/TH04-12-0838
Issue: 2005: 93/4 (Apr) pp. 625-798
Pages: 655-660

Tissue plasminogen activator in central nervous system physiology and pathology

Jerry P. Melchor, Sidney Strickland

Laboratory of Neurobiology and Genetics, The Rockefeller University, New York, New York, USA

Summary

Although conventionally associated with fibrin clot degradation, recent work has uncovered new functions for the tissue plasminogen activator (tPA)/plasminogen cascade in central nervous system physiology and pathology.This extracellular proteolytic cascade has been shown to have roles in learning and memory, stress, neuronal degeneration, addiction and Alzheimer’s disease. The current review considers the different ways tPA functions in the brain.