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Patients with unstable control have a poorer dietary intake of vitamin K compared to patients with stable control of anticoagulation

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
DOI: http://dx.doi.org/10.1160/TH04-12-0773
Issue: 2005: 93/5 (May) pp. 799-1009
Pages: 872-875

Patients with unstable control have a poorer dietary intake of vitamin K compared to patients with stable control of anticoagulation

Elizabeth Sconce, Tayyaba Khan, Jennifer Mason, Faye Noble, HilaryWynne1 , Farhad Kamali
School of Clinical and Laboratory Sciences, University of Newcastle uponTyne and 1 Care of the Elderly, RoyalVictoria Infirmary, Newcastle uponTyne, UK

Summary

Evidence suggests that alterations in the dietary intake of vitaminKcan affect anticoagulation response towarfarin.It is possible that a low and erratic intake of dietary vitamin K is at least partly responsible for the variable response to warfarin in patients with unstable control of anticoagulation. Twenty-six patientswith unstable and twenty-sixwith stable control of anticoagulation completed dietary records of all foods and drinks consumed on a daily basis for two consecutive weeks.The mean daily intake of vitamin K in unstable patients was considerably lower than that for stable patients during the study period (29±17 µ g v . 76±40µg).The logarithm of vitamin K intake was consistently and significantly lower in the unstable patients than the stable patients over the two week period (5.9± 0.4µg v. 6.9±0.5µg; p<0.001; 95% CI: 0.7–1.2). Changes in vitamin K intake between weeks 1 and 2 of the study were negatively correlated with changes in International Normalised Ratio (INR) amongst the unstable patients, however this failed to reach significance (r=-0.25; p=0.22).Daily supplementation with oral vitamin K in unstable patients could lead to a more stable anticoagulation response to warfarin.