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Infection of the endothelium by influenza viruses

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Topic:

Vascular Endothelium and Infectious Diseases

DOI: http://dx.doi.org/10.1160/TH05-04-0264
Issue: 2005: 94/2 (Aug) pp. 233-468
Pages: 262-265
Ahead of Print: ###MANUSCRIPT_aheadofprint###

Infection of the endothelium by influenza viruses

Hans-Dieter Klenk

Institut für Virologie, Philipps-Universität, Marburg, Germany

Summary

Highly pathogenic avian influenza viruses are not only the cause of devastating “bird flu” outbreaks in domestic fowl, but are also occasionally the cause of human disease with a high mortality rate as is being currently observed with the H5N1 viruses in South-East Asia. Infection in birds is systemic with hemorrhages and edema as characteristic symptoms, and virus replication in the endothelium appears to play an important role in pathogenesis. Some of the factors determining endotheliotropism have been elucidated at the molecular and cellular level.They include proteolytic activation of the hemagglutinin,polarity of virus budding, and tissue specific expression of virus receptors.