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Mechanism and consequences of invasion of endothelial cells by Staphylococcus aureus

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Topic:

Vascular Endothelium and Infectious Diseases

DOI: http://dx.doi.org/10.1160/TH05-04-0235
Issue: 2005: 94/2 (Aug) pp. 233-468
Pages: 266-277

Mechanism and consequences of invasion of endothelial cells by Staphylococcus aureus

Bhanu Sinha1, Mathias Herrmann2

1Institute of Medical Microbiology, University Hospital of Münster, Münster, 2Institute of Medical Microbiology and Hygiene, University of Saarland, Homburg; Germany

Summary

It has become clear that Staphylococcus aureus is a facultative intracellular microorganism. Adherence and invasion are a prerequisite for endovascular infections caused by S. aureus, such as infective endocarditis.These phenomena may also be involved in the pathogenesis of invasive and metastatic infection upon hematogenous dissemination, such as osteomyelitis and abscess formation.The underlying molecular mechanism has been elucidated in detail, including its likely relevance in vivo. However, the mode of action of recently identified modulators of invasion, such as pls/Pls have not yet been clarified.The potential outcome for host cells and S. aureus following invasion are diverse. Surprisingly, induction of apoptosis in human endothelial cells is more complex than previously thought, since it appears to involve multiple virulence factors. In the light of increasing resistance to antimicrobial therapy, understanding the multifacetted pathogenesis of S. aureus infection in detail is needed for a better prevention and therapy.