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Paracetamol (acetaminophen) and warfarin interaction: unraveling the pivotal role of the vitamin K cycle

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Topic:

Paediatric Haemostasis

DOI: http://dx.doi.org/10.1160/TH04-08-0472
Issue: 2004: 92/4 (Oct) pp. 672-895
Pages: 672-673

Paracetamol (acetaminophen) and warfarin interaction: unraveling the pivotal role of the vitamin K cycle

Elaine M. Hylek
Boston University School of Medicine, Department of Medicine, Section of General Internal Medicine and the Clinical Epidemiology Unit, Boston, Massachusetts, USA

Summary

Analgesia poses a clinical challenge for patients taking anticoagulants. Nonsteroidal anti-inflammatory drugs impair platelet function and also interfere with prostaglandin’s protective effect on the gastric mucosa. As a result, these medications increase the risk of gastrointestinal hemorrhage (1). In clinical practice, patients are advised to avoid or limit use of these agents because of the added risk of bleeding. Paracetamol (acetaminophen) is the antipyretic and analgesic of choice for patients on anticoagulant therapy because it lacks these adverse effects on platelets and prostaglandin. Paracetamol is readily available and widely used. . . .

DOI

http://dx.doi.org/10.1160/TH04-08-0472