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The factor VII activating protease G511E (Marburg) variant and cardiovascular risk

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
DOI: http://dx.doi.org/10.1160/TH04-05-0275
Issue: 2004: 92/5 (Nov) pp. 896-1169
Pages: 986-992

The factor VII activating protease G511E (Marburg) variant and cardiovascular risk

Helen Ireland(1), George J. Miller(2), Karen E.Webb(1), Jackie A. Cooper(1), Steve E. Humphries(1)
(1)Division of Cardiovascular Genetics, Department of Medicine, British Heart Foundation Laboratories, Royal Free and University College Medical School, London, UK (2)Medical Research Council Cardiovascular Group, Department of Environmental and Pre

Summary

A previous study had shown a strong relationship between a variant in factor VII activating protease (FSAP G511E) and advanced carotid atheroma. In-vitro, the variant has reduced fibrinolytic but normal pro-coagulant activity, which may constitute a prothrombotic state. The current study has addressed risk for coronary heart disease in a prospective study of cardio vascular disorders (Northwick Park Heart Study II). An interactive effect upon risk was found between the 511E allele and elevated levels of cholesterol and triglyceride. Fibrinogen could substitute for triglyceride levels in this risk-interaction analysis. The findings support the proposal that the FSAP 511E allele exacerbates atherosclerosis or its clinical sequelae.

DOI

http://dx.doi.org/10.1160/TH04-05-0275