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Effect of Interleukin-6 promoter polymorphisms in survivors of myocardial infarction and matched controls in the North and South of Europe The HIFMECH Study

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
DOI: http://dx.doi.org/10.1160/TH04-04-0202
Issue: 2004: 92/5 (Nov) pp. 896-1169
Pages: 1122-1128

Effect of Interleukin-6 promoter polymorphisms in survivors of myocardial infarction and matched controls in the North and South of Europe The HIFMECH Study

Daniel Kelberman1, E. Hawe1, L. A. Luong1,Vidya Mohamed-Ali2, Pia Lundman3, Per Tornvall4, M. F. Aillaud5, Irène Juhan-Vague5, John S.Yudkin2, Maurizio Margaglione6, Giovanni di Minno6, Elena Tremoli7, Stephen E. Humphries1 on behalf of the HIFMECH stud
1Centre for Cardiovascular Genetics, Department of Medicine, Royal Free and University College London Medical School, London, UK 2Diabetes and Cardiovascular Disease Academic Unit, Department of Medicine, University College London, London, UK 3King Gust

Summary

Elevated plasma IL-6 levels have been implicated in the pathogenesis of coronary heart disease.We have investigated the association of two polymorphisms in the promoter of IL-6 (-572G>C and -174G>C) with levels of inflammatory markers and risk of myocardial infarction (MI) in a European study of MI survivors and age-matched controls from two high-risk centres in the North of Europe, and two low risk centres in the South. IL-6 and CRP levels were similar in controls in both regions, but were higher in cases. For the -174G>C polymorphism the rare -174C allele showed a regional difference in allele frequency, being more common in the North European group (0.43 vs 0.28; p < 0.0005), where -174C allele carriers showed an apparent reduced risk of MI compared to -174GG homozygotes (OR 0.53, 95%CI 0.32, 0.86). No such effect was observed in the South or with the -572G>C in either group. Neither genotype was associated with a significant effect on plasma IL-6 levels in either cases or controls. Furthermore, no regional difference was observed in the frequency of the -572G>C SNP, suggesting that these polymorphisms are unlikely to be contributing to the observed increased risk of cardiovascular disease in Northern Europe.