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Diabetes duration may modify the association between genetic variation in the glycoprotein Ia subunit of the platelet collagen receptor and risk of severe diabetic retinopathy: a working hypothesis

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Issue: 2003: 89/1 (Jan) pp.1-205
Pages: 142-148

Diabetes duration may modify the association between genetic variation in the glycoprotein Ia subunit of the platelet collagen receptor and risk of severe diabetic retinopathy: a working hypothesis

Alexander P. Reiner(1), Elisabeth Agardh(2), Gayle Teramura(3), Prashart Gaur(3), Lakshmi K. Gaur(3), Carl-David Agardh(2)
(1)Departments of Epidemiology and Laboratory Medicine, University of Washington, Seattle,Washington, USA (2)Departments of Ophthalmology and Endocrinology, University Hospital MAS, Malmö, Sweden (3)Puget Sound Blood Center, Seattle,Washington,

Summary

Genetic factors appear to contribute to the severity and progression of diabetic retinopathy.We assessed the associations of the C807T and Glu505Lys variants of the glycoprotein Ia (2 integrin) subunit of the platelet/endothelial collagen receptor and risk of retinopathy in a population-based survey of 288 diabetic patients in one Swedish community. Neither variant was associated with retinopathy risk overall. However, the 807T variant was associated with increased risk of severe retinopathy, and the association was modified by diabetes duration. Among patients with diabetes of longer duration (25 years), the 807T variant was strongly associated with risk of severe retinopathy (odds ratio 7.49, 95% confidence interval1.75 to 32.1). There was no association between the 807T variant and risk of severe retinopathy among patients with diabetes duration <25 years. The Lys505 variant of glycoprotein Ia was associated with an odds ratio for severe retinopathy of 1.88 (95% confidence interval 0.83 to 4.24). Overall, there was a significant interaction between glycoprotein Ia genotype and duration of diabetes on the risk of retinopathy (P-value for interaction = 0.019).These results suggest the hypothesis that genetic variation of platelet glycoprotein Ia may play a particularly important role during the advanced stages of diabetic retinopathy.