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Enhanced nutritionally induced adipose tissue development in mice with stromelysin-1 gene inactivation

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Issue: 2003: 89/4 (Apr) pp.596-770
Pages: 696-704

Enhanced nutritionally induced adipose tissue development in mice with stromelysin-1 gene inactivation

Erik Maquoi, Diego Demeulemeester, Gabor Vörös, Désire Collen, H. Roger Lijnen
Center for Molecular and Vascular Biology, University of Leuven, Leuven, Belgium

Summary

To investigate a potential role of stromelysin-1 (MMP-3) in development of adipose tissue, 5 week old male MMP-3 deficient mice (MMP-3-/-) and wild-type (MMP-3+/+) controls were kept on a high fat diet (HFD) for 15 weeks.MMP-3-/- mice were hyperphagic and gained more weight than the MMP-3+/+ mice. At the time of sacrifice, the body weight of the MMP-3-/- mice was significantly higher than that of the MMP-3+/+ mice, as was the weight of the isolated subcutaneous (SC) and gonadal (GON) fat deposits. Significant adipocyte hypertrophy was observed in the GON but not in the SC adipose tissue of MMPCorrespondence