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Soluble E-selectin in cardiovascular disease and its risk factors A review of the literature

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Topic:

Wound Healing Mechanisms

DOI: http://dx.doi.org/10.1160/TH02-09-0083
Issue: 2003: 90/6 (Dec) pp. 967-1257
Pages: 1007-1020

Soluble E-selectin in cardiovascular disease and its risk factors A review of the literature

Vanessa Roldán (1, 2) , Francisco Marín (1, 3) , Gregory Y. H. Lip (1) , Andrew D. Blann (1)
(1) Haemostasis,Thrombosis and Vascular Biology Unit, University Department of Medicine, City Hospital, Birmingham, UK (2) Hematology Unit, Hospital San Vicente, Spain (3) Cardiology Unit, Hospital General Alicante, Spain

Summary

The initial steps in the pathogenesis of atherosclerosis involve changes to the vascular endothelium, which produces numer-ous substances involved in the regulation and maintenance of vascular integrity and the homeostasis of the coagulation/fibri-nolysis system. A further change in endothelial physiology is an increase in the surface expression of cell adhesion molecules, such as E-selectin, which regulate adhesive interactions between certain blood cells and endothelium. As E-selectin is only expressed on activated endothelium, it therefore provides an opportunity to study pathophysiological aspects of this cell in cardiovascular and other disease. However, a soluble form of E selectin (i.e. sE-selectin) can be found in the plasma. This review will focus on sE-selectin, and its potential role in the pathogenesis of cardiovascular disease as raised levels have been found in hypertension, diabetes and hyperlipidemia, although its association in established atherosclerosis disease and its value as a prognostic factor is more controversial.

DOI

http://dx.doi.org/10.1160/TH02-09-0083