Procoagulant Activity and Cytokine Expression in Whole Blood Cultures from Patients with Atherosclerosis Supplemented with Omega-3 Fatty Acids
Ingebjørg Seljeflot, Odd Johansen (1) , Harald Arnesen (1) , Jan-Bertil Eggesbø (2) , Åse-Britt Westvik (2) , Peter Kierulf (2)
From the Research Forum, (1) Dept of Medicine, (2) Research and Development Group, Dept of Clinical Chemistry, Ullevål University Hospital, Oslo, Norway
Omega-3 fatty acids (n-3 FA) may reduce atherogenesis and thrombosis.
We investigated the effects of n-3 FAs on procoagulant activity
and cytokine expression in whole blood cultures from patients with
atherosclerosis. Eleven of the 23 included patients had received 5.1 g
n-3 FA daily for 6 months (group I) whereas 12 patients had been on
placebo (group II). All patients were then given 5.1g n-3 FA daily for
another 4 weeks.
At baseline significantly lower levels of LPS-induced prothrombin
fragment 1+2 were found in group I (p = 0.010), this difference being
eliminated after 4 weeks. Il-6 and TNF a were significantly higher at
baseline in group I and the differences in changes from baseline between
the groups were statistically highly significant with increasing
values in group II (Il-6 p = 0.001, TNF a p = 0.002).
The present results indicate a reduction in pro-thrombotic potential
in patients receiving highly concentrated n-3 FA, whereas some proinflammatory
responses might be adverse.