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Archive

Immunology of the Antiphospholipid Syndrome: Antibodies, Antigens, and Autoimmune Response

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Issue: 1999: 82/2 (Aug) pp.165-1004
Pages: 656-661

Immunology of the Antiphospholipid Syndrome: Antibodies, Antigens, and Autoimmune Response

Robert A. S. Roubey
Division of Rheumatology and Immunology, The University of North Carolina at Chapel Hill, Chapel Hill, NC, USA

Summary

Introduction: The antiphospholipid syndrome (APS) is an autoimmune condition in which a group of autoantibodies are thought to play a direct role in the pathogenesis of thrombosis, fetal loss, and other clinical manifestations. This review will focus on the nature of these autoantibodies, the antigens they recognize, and mechanisms that may contribute to autoimmunity and the production of autoantibodies in patients with APS.