Solid Tumors and Factor VIII Antibodies
Irene Hauser, Klaus Lechner
From the Division of Hematology/Blood Coagulation, I. Department of Internal Medicine, University of Vienna, Austria
Purpose: To analyze the association between solid tumors and the
occurrence of factor VIII antibodies and the response to treatment.
Patients and Methods: Published case reports describing the
association of a solid tumor and a factor VIII antibody retrieved from
20 data bases. 40 cases were reported and 27 cases were analyzable.
Results: Factor VIII antibodies occurred in a close temporal relationship
with the detection of the tumor in most cases. No association
with a specific type of tumor could be identified. Immune suppressive
treatment with prednisone ± cyclophosphamide was successful in the
majority of cases.
Conclusion: It is likely that there is a causal association between
some solid tumors and factor VIII antibodies, but it is an extremely
rare complication of cancer. The immunoglobuline nature of the inhibitor
and the good response to immune suppressive treatment suggests
that it is an autoimmune phenomenon. The pathogenesis is unknown.