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Automated Latex Agglutination and ELISA Testing Yield Equivalent D-Dimer Results in Patients with Recent Myocardial Infarction

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Issue: 1999: 82/5 (Nov) pp.1380-1561
Pages: 1412-1416

Automated Latex Agglutination and ELISA Testing Yield Equivalent D-Dimer Results in Patients with Recent Myocardial Infarction

Victor J. Marder (1) , Wojciech Zareba (2) , John T. Horan (2) , Arthur J. Moss (2) ,Joel J. Kanouse (1) , for the THROMBO Research Investigators
From the (1) Orthopaedic Hospital/UCLA School of Medicine, Los Angeles, CA and (2) University of Rochester School of Medicine & Dentistry, Rochester, NY, USA

Summary

Our previous prospective study of post-infarction patients described a strong and significant association of increased plasma D-dimer concentrations in those who experienced a subsequent coronary death or non-fatal myocardial infarction. In the present study, we compare results on stored plasma obtained two months after the index myocar-dial infarction from 1,038 patients of this trial, using a simple automated latex agglutination (LA) assay in parallel with the standard ELISA test. Results show a somewhat higher mean value for the LA assay (702 ± 1092 vs. 638 ± 986 ng/ml, p = 0.0002), a strong linear correlation of the two assays (r = 0.86) and 88% agreement for values below 500 ng/ml by the ELISA test. D-dimer concentrations determined by each assay were highly correlated in patients with subsequent coronary artery events (p = 0.93) and quartile values for both the LA and ELISA were equally predictive of such events (p = 0.003 and p = 0.001, respectively). This is the first demonstration that a latex agglutination assay for D-dimer can be used to assess the prognostic risk of recurrent coronary thrombotic disease after myocardial infarction