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Advances in imaging angiogenesis and inflammation in atherosclerosis

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Topic:

Theme Issue
Intravital imaging of inflammation

DOI: http://dx.doi.org/10.1160/TH10-08-0562
Issue: 2011: 105/5(May) pp. 743-932
Pages: 820-827

Advances in imaging angiogenesis and inflammation in atherosclerosis

L. Zagorchev (1, 2, 3), M. J. Mulligan-Kehoe (4)

(1) Thayer School of Engineering, Dartmouth College, Hanover, New Hampshire, USA; (2) Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA; (3) Philips Research North America, Briarcliff, New York, USA; (4) Department of Surgery, Vascular Section, Dartmouth Medical School, Dartmouth-Hitchcock Medical Center, Lebanon, New Hampshire, USA

Keywords

Atherosclerosis, angiogenesis, inflammation, imaging

Summary

Advances in imaging technology have provided powerful tools for dissecting the angiogenic and inflammatory aspects of atherosclerosis. Improved technology along with multi-modal approaches has expanded the utilisation of imaging. Recent advances provide the ability to better define structure and development of angiogenic vessels, identify relationships between inflammatory mediators and the vessel wall, validate biological effects of anti-inflammatory and anti-angiogenic drugs, delivery and/or targeting specific molecules to inflammatory regions of atherosclerotic plaques.

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