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Alcohol consumption, types of alcoholic beverages and risk of venous thromboembolism – The Tromsø Study

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Topic:

Theme Issue
Platelet function testing: From bench to bedside

DOI: https://doi.org/10.1160/TH11-01-0043
Issue: 2011: 106/2 (Aug) pp. 185-387
Pages: 272-278

Alcohol consumption, types of alcoholic beverages and risk of venous thromboembolism – The Tromsø Study

I. J. Hansen-Krone (1), S. K. Brækkan (1, 2), K. F. Enga (1), T. Wilsgaard (3), J.-B. Hansen (1, 2)

(1) Hematological research group (HERG), Department of Clinical Medicine, University of Tromsø, Tromsø, Norway; (2) Division of Internal Medicine, University Hospital of North Norway, Tromsø, Norway; (3) Department of Community Medicine, University of Tromsø, Tromsø, Norway

Keywords

Risk Factors, venous thromboembolism, Alcohol, prospective cohort

Summary

Moderate alcohol consumption has been shown to protect against cardiovascular diseases. The association between alcohol consumption, especially types of alcoholic beverages, and venous thromboembolism (VTE) is less well described. The aim of this study was to investigate the impact of alcohol consumption and different alcoholic beverages on risk of VTE. Information on alcohol consumption was collected by a self-administrated questionnaire in 26,662 subjects, aged 25–97 years, who participated in the Tromsø Study, in 1994–1995. Subjects were followed through September 1, 2007 with incident VTE as the primary outcome. There were 460 incident VTE-events during a median of 12.5 years of follow-up. Total alcohol consumption was not associated with risk of incident VTE. However, subjects consuming ≥3 units of liquor per week had 53% increased risk of VTE compared to teetotalers in analyses adjusted for age, sex, body mass index, smoking, diabetes, cancer, previous cardiovascular disease, physical activity and higher education (HR: 1.53, 95% CI: 1.00–2.33). Contrary, subjects with a wine intake of ≥3 units/week had 22% reduced risk of VTE (HR: 0.78, 95% CI: 0.47–1.30), further adjustment for liquor and beer intake strengthened the protective effect of wine (HR: 0.53, 95% CI: 0.30–1.00). Frequent binge drinkers (≥1/week) had a 17% increased risk of VTE compared to teetotallers (HR 1.17, 95% CI: 0.66–2.09), and a 47% increased risk compared to non-binge drinkers (HR 1.47, 95% CI: 0.85–2.54). In conclusion, liquor consumption and binge drinking was associated with increased risk of VTE, whereas wine consumption was possibly associated with reduced risk of VTE.

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