Reduced bone mineral density in patients with haemophilia A and B in Northern Greece

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Issue: 2012: 107/3 (Mar) pp. 397-599
Pages: 545-551

Reduced bone mineral density in patients with haemophilia A and B in Northern Greece

P. Anagnostis (1), S. Vakalopoulou (2), A. Slavakis (3), M. Charizopoulou (4), E. Kazantzidou (5), T. Chrysopoulou (5), T.-A. Vyzantiadis (6), E. Moka (2), A. Agapidou (2), V. Garipidou (2)

(1) Department of Endocrinology, Hippokration Hospital, Thessaloniki, Greece; (2) Division of Haematology, 2 nd Propedeutic Department of Internal Medicine, Aristotle University, Hippokration Hospital, Thessaloniki, Greece; (3) Department of biochemistry, Hormone Assay Laboratory, Hippokration Hospital, Thessaloniki, Greece; (4) Department of Psychology, School of Philosophy, Aristotle University, Thessaloniki, Greece; (5) Radiology Department, Hippokration Hospital, Thessaloniki, Greece; (6) 1st Department of Microbiology, Medical School, Aristotle University, Thessaloniki, Greece


Osteoporosis, Haemophilia, bone mass, Osteopenia


Haemophilia A and B has been associated with increased prevalence of low bone mass (67–86%). The aim of this study was to estimate the prevalence of bone disease in haemophiliacs and its association with potential risk factors. Adult patients with haemophilia A and B followed-up in the Haemophilia Centre of Northern Greece were included. Bone mineral density (BMD) was measured by dual-energy X-ray absorptiometry (DXA) in lumbar spine (LS), femoral neck (FN), total hip (TH) and great trochanter (GT). One-hundred four male patients (aged 45.8 ± 15.1 years) and 50 controls (aged 44.9 ± 12.8 years) were screened. Low BMD was diagnosed in 28 patients (26.9%) and 10 controls (20%) (p=0.0001). Patients had lower BMD in TH (p=0.007), FN (p=0.029) and GT (p=0.008) than controls, without differences in LS. BMD was positively associated with the severity of haemophilia, history of herpes virus C or human immunodeficiency virus and level of physical activity, and negatively with the level of arthropathy. In multiple-regression analysis, only the level of physical activity and 25-hydroxyvitamin D [25(OH)D] significantly predicted BMD. Half of the patients had vitamin D deficiency. In conclusion, our study showed increased prevalence of low BMD in haemophiliacs. The levels of physical activity and 25(OH)D independently predicted low BMD.

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