Infections and inflammatory diseases as risk factors for venous thrombosis

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Issue: 2012: 107/5(May) pp. 803-1007
Pages: 827-837

Infections and inflammatory diseases as risk factors for venous thrombosis

A systematic review

See also Editorial by Ageno et al.

Y. I. G. V. Tichelaar (1), H. J. C. Kluin-Nelemans (1), K. Meijer (1)

(1) Department of Hematology, Division of Hemostasis and Thrombosis, University Medical Center Groningen, Groningen, the Netherlands


Risk Factors, Venous thrombosis, Infections, inflammatory diseases


Inflammation and venous thrombosis are intertwined. Only in the recent 15 years clinical epidemiological studies have focussed on inflammatory or infectious diseases as risk factors for venous thrombosis. Although a few reviews and many case reports or studies on these topic has been written, a review reporting relative or absolute risks for venous thrombosis has not been published yet. We performed a systematic review using Medline, Pubmed and Embase and found 31 eligible articles. Inflammatory bowel disease, ANCA-associated vasculitis, infections in general and more specifically, human immunodeficiency virus, pneumonia and urinary tract infections are associated with an increased risk of venous thrombosis.

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