Comparison of two methods for selection of out of hospital treatment in patients with acute pulmonary embolism

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Issue: 2013: 109/1 (Jan) pp. 1–173
Pages: 47-52

Comparison of two methods for selection of out of hospital treatment in patients with acute pulmonary embolism

W. Zondag (1), P. L. den Exter (1), M. J. T. Crobach, A. Dolsma (2), M. L. Donker, M. Eijsvogel (3), L. M. Faber (4), H. M. A. Hofstee (5), K. A. H. Kaasjager, M. J. H. A. Kruip (6), G. Labots, C. F. Melissant (7), M. S. G. Sikkens, M. V. Huisman (1), on behalf of The Hestia Study Investigators

(1) Department of Thrombosis and Hemostasis, Leiden University Medical Center (LUMC), Leiden, The Netherlands; (2) Department of Pulmonology, Diaconessenhuis, Leiden, The Netherlands; (3) Department of Pulmonology, Medical Spectrum Twente, Enschede, The Netherlands; (4) Department of General Internal Medicine, Rode Kruis Hospital, Beverwijk, The Netherlands; (5) Department of Internal Medicine, VU University Medical Center, Amsterdam, The Netherlands; (6) Department of Hematology, Erasmus Medical Centre, Rotterdam, The Netherlands; (7) Department of Pulmonology, Spaarne Hospital, Hoofddorp, The Netherlands


Mortality, pulmonary embolism, thrombosis, outpatient treatment


The aim of this study is to compare the performance of two clinical decision rules to select patients with acute pulmonary embolism (PE) for outpatient treatment: the Hestia criteria and the simplified Pulmonary Embolism Severity Index (sPESI). From 2008 to 2010, 468 patients with PE were triaged with the Hestia criteria for outpatient treatment: 247 PE patients were treated at home and 221 were treated as inpatients. The outcome of interest was all-cause 30-day mortality. In a post-hoc fashion, the sPESI items were scored and patients were classified according to the sPESI in low and high risk groups. Of the 247 patients treated at home, 189 (77%) patients were classified as low risk according to the sPESI and 58 patients (23%) as high risk. In total, 11 patients died during the first month; two patients treated at home and nine patients treated in-hospital. None of the patients treated at home died of fatal PE. Both the Hestia criteria and sPESI selected >50% of patients as low risk, with good sensitivity and negative predictive values for 30-day mortality: 82% and 99% for the Hestia criteria and 91% and 100% for the sPESI, respectively. The Hestia criteria and the sPESI classified different patients eligible for outpatient treatment, with similar low risks for 30-day mortality. This study suggests that the Hestia criteria may identify a proportion of high risk sPESI patiennts who can be safely treated at home, this however requires further validation.

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