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Platelets, inflammation and anti-inflammatory effects of antiplatelet drugs in ACS and CAD

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Topic:

Theme Issue
Platelets, inflammation and anti-inflammatory drugs in ACS and CAD

DOI: https://doi.org/10.1160/TH14-11-0947
Issue: 2015: 114/3 (Sep) pp. 445–656
Pages: 498-518
Ahead of Print: 2015-07-30

Platelets, inflammation and anti-inflammatory effects of antiplatelet drugs in ACS and CAD

Theme Issue Article to Theme Issue "Platelets, Inflammation and anti-inflammatory drugs in ACS and CAD"

K. A. L. Müller (1, 2), M. Chatterjee (1), D. Rath (1), T. Geisler (1)

(1) Medizinische Klinik III, Abteilung für Kardiologie und Kreislauferkrankungen, Universitätsklinikum Tübingen, Tübingen, Germany; (2) La Jolla Institute for Allergy and Immunology, La Jolla, California, USA

Keywords

Atherosclerosis, inflammation, cytokines, platelet physiology, Antiplatelet agents

Summary

Platelets play a pivotal role in chronic inflammation leading to progression of atherosclerosis and acute coronary events. Recent discoveries on novel mechanisms and platelet-dependent inflammatory targets underpin the role of platelets to maintain a chronic inflammatory condition in cardiovascular disease. There is strong and clinically relevant crosslink between chronic inflammation and platelet activation. Antiplatelet therapy is a cornerstone in the prevention and treatment of acute cardiovascular events. The benefit of antiplatelet agents has mainly been attributed to their direct anti-aggregatory impact. Some anti-inflammatory off-target effects have also been described. However, it is unclear whether these effects are secondary due to inhibition of platelet activation or are caused by direct distinct mechanisms interfering with inflammatory pathways. This article will highlight novel platelet associated targets that contribute to inflammation in cardiovascular disease and elucidate mechanisms by which currently available antiplatelet agents evolve anti-inflammatory capacities, in particular by carving out the differential mechanisms directly or indirectly affecting platelet mediated inflammation. It will further illustrate the prognostic impact of antiplatelet therapies by reducing inflammatory marker release in recent cardiovascular trials.

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