Anzeige
Anzeige

Archive

Small but mighty: Platelets as central effectors of host defense

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
DOI: https://doi.org/10.1160/TH16-12-0921
Issue: 2017: Issue 4 2017 (pp. 647-821)
Pages: 651-661
Ahead of Print: 2017-02-16

Small but mighty: Platelets as central effectors of host defense

T. J. Stocker (1), H. Ishikawa-Ankerhold (1), S. Massberg (1, 2), C. Schulz (1, 2)

(1) Medizinische Klinik und Poliklinik I, Klinikum der Universität, Ludwig Maximilians-Universität, Munich, Germany; (2) DZHK (German Center for Cardiovascular Research), Partner Site Munich Heart Alliance, Munich, Germany

Keywords

inflammation, Platelet immunology, leukocyte function / activation, sepsis, platelet physiology

Summary

Platelets actively participate in inflammatory processes and drive diseases such as atherosclerosis, rheumatoid arthritis and cancer metastasis. However, platelets also have anti-inflammatory and anti-infective properties, which have received less consideration in the past. In this review, we highlight recent findings on the role of platelets in host defense and describe regulatory pathways modulating immune responses. Furthermore, we discuss the role of platelets for the resolution of inflammation and tissue repair. These conceptual changes contribute to our understanding of platelet biology in disease.

You may also be interested in...

1.

Theme Issue Article for Theme Issue "Infections and the role of plasma proteins and platelets"

D. Duerschmied (1), C. Bode (1), I. Ahrens (1)

Thromb Haemost 2014 112 4: 678-691

https://doi.org/10.1160/TH14-02-0146

2.

Bettina Temmesfeld-Wollbrück, Andreas C. Hocke, Norbert Suttorp, Stefan Hippenstiel

Thromb Haemost 2007 98 5: 944-951

https://doi.org/10.1160/TH07-02-0128

3.
Alexander D. Cornet, Ellen G. M. Smit, Albertus Beishuizen, A. B. Johan Groeneveld

Thromb Haemost 2007 98 3: 579-586

https://doi.org/10.1160/TH07-01-0006