Fibrinolysis and host response in bacterial infections

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245

Haemostasis, vascular biology, and infectious agents - Thrombophilia and anticoaulant pathway

Issue: 2007: 98/3 (Sep) pp. 483-704
Pages: 512-520

Fibrinolysis and host response in bacterial infections

Simone Bergmann, Sven Hammerschmidt

Max von Pettenkofer Institute, Ludwig-Maximilians-University of Munich, Munich, Germany


The plasminogen activation system is part of the fibrinolysis which is tightly regulated and protected against dysfunction by various activators and inhibitors. However, microorganisms including bacteria, fungi and also parasites have been proven to interact in a specific manner with components of the fibrinolytic pathways. Pathogenic bacteria are capable to subvert the function of proteases, activators or inhibitors for their own benefits including dissemination within the host and evasion of host inflammatory immune response. Here, we provide a state of the art overview of the divers strategies employed by bacteria to interact with components of the fibrinolytic system and to exploit the system for invasion. Moreover, the role of factors of the fibrinolytic cascade in inflammatory host response due to different bacterial infections will be presented.