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Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Issue: 2015: 113/5 (May) pp. 911–1157
Pages: 1135-1144
Ahead of Print: 2015-02-19

Menaquinone-7 supplementation improves arterial stiffness in healthy postmenopausal women

A double-blind randomised clinical trial

M. H. J. Knapen (1), L. A. J. L. M. Braam (1), N. E. Drummen (1), O. Bekers (2), A. P. G. Hoeks (3), C. Vermeer (1)

(1) VitaK & Cardiovascular Research Institute (CARIM), Maastricht University, The Netherlands; (2) Central Diagnostic Laboratory, University Hospital Maastricht, The Netherlands; (3) Biomedical Engineering, Maastricht University, The Netherlands


carotid intima-media thickness, Arterial stiffness, menaquinone-7, pulse wave velocity, Stiffness Index β


Observational data suggest a link between menaquinone (MK, vitamin K2) intake and cardiovascular (CV) health. However, MK intervention trials with vascular endpoints are lacking. We investigated long-term effects of MK-7 (180 µg MenaQ7/day) supplementation on arterial stiffness in a double-blind, placebo-controlled trial. Healthy postmenopausal women (n=244) received either placebo (n=124) or MK-7 (n=120) for three years. Indices of local carotid stiffness (intima-media thickness IMT, Diameter end-diastole and Distension) were measured by echotracking. Regional aortic stiffness (carotid-femoral and carotid-radial Pulse Wave Velocity, cfPWV and crPWV, respectively) was measured using mechanotransducers. Circulating desphospho-uncarboxylated matrix Gla-protein (dp-ucMGP) as well as acute phase markers Interleukin-6 (IL-6), high-sensitive C-reactive protein (hsCRP), tumour necrosis factor-α (TNF-α) and markers for endothelial dysfunction Vascular Cell Adhesion Molecule (VCAM), E-selectin, and Advanced Glycation Endproducts (AGEs) were measured. At baseline dp-ucMGP was associated with IMT, Diameter, cfPWV and with the mean z-scores of acute phase markers (APMscore) and of markers for endothelial dysfunction (EDFscore). After three year MK-7 supplementation cfPWV and the Stiffness Index βsignificantly decreased in the total group, whereas distension, compliance, distensibility, Young’s Modulus, and the local carotid PWV (cPWV) improved in women having a baseline Stiffness Index β above the median of 10.8. MK-7 decreased dp-ucMGP by 50 % compared to placebo, but did not influence the markers for acute phase and endothelial dysfunction. In conclusion, long-term use of MK-7 supplements improves arterial stiffness in healthy postmenopausal women, especially in women having a high arterial stiffness.

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