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Plasma Levels of Syndecan-4 (Ryudocan) Are Elevated in Patients with Acute Myocardial Infarction

Journal: Thrombosis and Haemostasis
ISSN: 0340-6245
Issue: 2001: 85/5 (May) pp.756-946
Pages: 793-799

Plasma Levels of Syndecan-4 (Ryudocan) Are Elevated in Patients with Acute Myocardial Infarction

Tetsuhito Kojima (1), (2) , Akira Takagi (1) , Masahiro Maeda (3) , Tatsuya Segawa (3) , Atsuya Shimizu (2) , Koji Yamamoto (2) , Tadashi Matsushita (2) , Hidehiko Saito (2), (4)
(1) Department of Medical Technology, Nagoya University School of Health Sciences, (2) First Department of Internal Medicine, Nagoya University School of Medicine, Nagoya, (3) Immuno-Biological Laboratories, Co. Ltd., Fujioka, (4) Aichi Juridical Founda


Syndecan-4 (ryudocan) is a cell-surface heparan sulfate proteoglycan, which plays an important role in a variety of biological functions including regulation of blood coagulation, cell adhesion, and cell growth. In this study, we measured plasma levels of syndecan-4 in patients with acute myocardial infarction using an enzyme-immunoassay, and found that they were extremely high, with a peak of average (10.5 ± 5.6 ng/ml, 2 weeks after onset), as compared with those in normal subjects (0.078 ± 0.030 ng/ml) (p < 0.001). We also observed a distinct expression of syndecan-4 in the repair region of the damaged cardiac tissues with infarction, but not in intact region, by immunohistochemical analysis. To clarify the mechanism of syndecan-4 induction, we investigated the hypoxia effect on its expression, and found that hypoxia treatment up-regulated the gene expression of syndecan-4 in various types of cells. Taken together, it is suggested that syndecan-4 is induced by hypoxia stimuli in ischemic heart tissues, and may function as a tissue_repair molecule via biological mediators such as heparin-binding growth factors.