Univ.-Prof. Dr. med. Christian Weber, MD, FESC

Institute for Cardiovascular Prevention, Ludwig-Maximilians-University, Munich, Germany



Education & Degrees

1986 - 1993

Medical School, Ludwig-Maximilians-University (LMU), Munich

1994

MD thesis at LMU Munich ('summa cum laude')

1999

Facultas docendi and Venia legendi in Experimental Medicine

2003

Board Certification in Internal Medicine

2004

Board Certification in Cardiology



Professional Career

1993 - 1994

Internship in Internal Medicine, Dept. Cardiovascular Medicine, LMU Munich

1995 - 1997

Postdoctoral fellow at the Center for Blood Research, Harvard Medical School

1997 - 2001

Fellow in Internal Medicine, Department of Internal Medicine, LMU Munich

2001 - 2005

Associate Professor (C3) for Molecular Cardiovascular Research and Fellow, Dept. Cardiology, RWTH University Hospital Aachen

2004 - 2005

Offers for Chairs in Cardiology, University of Virginia and King's College London

2005 -

Chair (W3) and Director, Institute for Molecular Cardiovascular Research (IMCAR), Preventive Cardiology, RWTH Aachen University, Aachen

2006 -

Professor at Cardiovascular Research Institute Maastricht (CARIM) & Director, Maastricht Center for Atherosclerosis Research (M-CAR), Maastricht University

2007

Offer for Chair in Molecular Cardiology & Physiology, University of Düsseldorf

2007 -

Spokesman, DFG Centre Grant FOR809 Chemokines in Vascular Pathology

2008 -

Spokesman, DFG International Graduate School GRK1508 Arterial Remodeling

2010 -

Chair in Vascular Medicine & Director Institute for Cardiovasc. Prevention, LMU



Honours and Activities

2003

GlaxoSmithKline Basic Research Award, Fellow European Society of Cardiology

2004 - 2005

Arthur-Weber-Award, German Cardiac Society & Forßmann-Award

2007 - 2008

President, Society of Microcirculation & Vascular Biology (GfMVB)

2007 -

Co-Founder and SAB Carolus Therapeutics Inc.

2008

Paul-Martini-Award & ESC Outstanding Achievement Award

2008 - 2011

Scientific Committee Member, European Atherosclerosis Society

2009

Galenus-von-Pergamon-Prize & AHA Special Recognition Award Arteriosclerosis

2010

ERC Advanced Investigator Grant, VICI Award by NWO - The Netherlands

2012 - 2014

Chair, Working ESC Group on Atherosclerosis & Vascular Biology

Editorial Boards

Thrombosis & Haemostasis (Editor-in-Chief), Molecular Metabolism (European Editor), Arteriosclerosis, Thrombosis & Vascular Biology (Senior Editor)
Circulation Research, EMBO Mol Med, European Heart Journal (Guest Editor)

Bibliography

247 original articles & 135 review articles, plenary lectures at Gordon & Keystone conferences, cum. IF >2.900, citations >17.700, h-index 72, m-index 3.1 (Scopus)



Important Publications

  1. Ostermann G, Weber KSC, Zernecke A, Schröder A, Weber C. JAM-1 is a ligand for the ?2 integrin LFA-1 involved in transendothelial migration of leukocytes. Nature Immunol. 2002;3:151-158.
  2. Bernhagen J et al. & Weber C. MIF is a non-cognate ligand of CXC chemokine receptors in inflammatory and atherogenic cell recruitment. Nature Med. 2007;13:587-96.
  3. Weber C, Zernecke A, Libby P. The multi-facetted contributions of leukocyte subsets to athero¬sclerosis. Nature Rev. Immunol. 2008;8:802-815.
  4. Koenen RR et al. & Weber C. Disrupting functional inter¬actions between platelet chemokines inhibits atherosclerosis in hyperlipidemic mice. Nature Med. 2009;15:97-103.
  5. Zernecke A et al. & Weber C. Delivery of microRNA-126 by apoptotic bodies induces CXCL12-dependent vascular protection. Science Sign. 2009;2:ra81.
  6. Schober A et al. & Weber C (2014) MicroRNA-126-5p promotes endothelial proliferation and limits atherosclerosis by suppressing Dlk1. Nature Med. 2014; in press.



Funding History

1995 - 1997

Deutsche Forschungsgemeinschaft (DFG) Scholarship WE1913/1-1

1997 - 2001

Head of DFG Junior Research Group in Biomedical Sciences WE1913/2-1&2

1999 - 2001

DFG GRK-438 Vascular Biology in Medicine, Project A1

2002 - 2004

DFG Project Grant WE1913/2-3 (Integrin function in atherogenic recruitment)

2003 - 2006

DFG Project Grant WE1913/5-1&2 (Functional role of platelet chemokines)

2004 - 2007

DFG Project Grant BE1977/2-1 (MIF in atherosclerosis, with Dr. J. Bernhagen)

2004 - 2007

DFG Project Grant WE1913/7-1&2 (SDF-1 and vascular progenitor cells)

2005 - 2011

DFG SFB542, Project C12 (YB-1 & RANTES expression, with Dr. P. Mertens)

2006

HBFG 148/711-1 (Fluorescence-activated cell sorter FACSAria)

2006 - 2009

DFG Project Grant WE 1913/9-1&2 (JAM-A in inflammation / atherosclerosis)

2007 - 2010

DFG Program Grant FOR809 Chemokines in Vascular Pathology (Spokesman)

2007

HBFG 222/778-1 (2-photon-laser scanning microscope, with Dr. S. Uhlig)

2008 - 2009

DFG Project Grant WE 1913/13-1 (Metalloprotease function in inflammation)

2008 - 2011

DFG SFB542, Project A7 (MIF and glomerulonephritis, with Dr. J. Bernhagen)

2008 - 2011

DFG SFB542, Project A12 (Metalloprotease function, with Dr. A. Ludwig)

2009 - 2011

DFG Excellence Initiative Molecular Science & Engineering MSE06

2008 - 2012

DFG TRR57, Project P7 (MIF receptors in organ fibrosis, with Dr. H. Wasmuth)

2009 - 2013

DFG European Graduate School GRK1508 Arterial Remodeling (Spokesman)

2010 - 2015

European Research Council (ERC) Advanced Investigator Grant

2010 - 2015

VICI Grant, Nederlandse Organisatie voor Wetenschappelijk Onderzoek (NWO)

2010 - 2015

Leducq Transatlantic Network of Excellence (European Coordinator)

2011 - 2014

DFG Program Grant FOR809 Chemokines in Vascular Pathology (Spokesman)

2012 - 2016

DFG SFB914, Project B8 (Monocytes in atherosclerosis, with Dr. O. Soehnlein)

2013 - 2016

DFG SFB1054, Project B4 (Dendritic cell and T-cell plasticity in atherosclerosis)

Total funding

German Research Foundation (DFG) approx. 14 Mio. €
BMBF, ERC, NWO, Leducq, Industry, etc. approx. 18 Mio. €



Biosketch

Christian Weber is Director of the Institute for Cardiovascular Prevention and the Chair in Vascular Medicine at Ludwig-Maximilians-University (LMU) in Munich, Germany, since 2010. After graduating and completing his training in internal medicine at LMU and Harvard Medical School, Boston, he was board-certified in clinical cardiology and appointed as a Chair in Molecular Cardiology at RWTH Aachen University. As a Dutch VICI laureate, he also serves as a Professor at the Cardiovascular Research Institute Maastricht (CARIM) at Maastricht University. His group has a strong interest in the molecular interactions and pathophysiological functions of chemokines and immune cell subsets, as well as the role of microRNAs and their targets in vascular disease, namely atherosclerosis, while his clinical interests are focused on developing novel biomarkers and peptide-based biopharmaceuticals. Among many other awards, he is an ERC Advanced Investigator with > 380 publications, Senior Editor of ATVB, Editor-in-Chief of Thrombosis & Haemostasis and co-founder of Carolus Therapeutics.